Figure 3
From: Immune monitoring using the predictive power of immune profiles
Immune profiles are distinct in relative and absolute composition of immune markers. Immune markers from each subject in a designated profile were evaluated for statistical significance. (A) Comparisons of immune marker cell counts. Box and whisker plots show mean, maximum, and minimum values for each data set. Box represents the 25th to 75th percentile range. HV = healthy volunteers only. * = p < 0.05 and ** = p < 0.0001. Each profile was compared to the healthy volunteer cohort. (B) Comparisons of immune marker percentages. Box and whisker plots show mean, maximum, and minimum values for each data set. Box represents the 25th to 75th percentile range. HV = healthy volunteers only. * = p < 0.05 and ** = p < 0.0001. Each profile was compared to the healthy volunteer cohort. (C) Visualization of immune profiles size and composition. To develop a picture of the composition within immune profiles, selected immune markers (in cells/μl) were totaled within an individual, and the mean of the individuals were calculated within a profile. The average profile was used to reconstruct the exemplar within each profile. Graph size represents total leukocytes/μl for the average profile relative to the average of Profile 1. Graphs on the left show the three major components of leukocytes. Graphs on the right show selected proportions of mononuclear cells. See Additional file 8: Figure S4 for graphical characterization and statistical analysis of this data.